Description:
Modify the surface of the Desclaymr scaffold to improve drug delivery
? modify all polymeric scaffolds
Technical Field
Regenerative Medicine, Biotech
Business opportunity
Research collaboration to validate the
technology
Current state of technology
The lab has this technology within 4 separate studies: One
polycaprolactone (PCL) version of the technology demonstrates vastly improved
retention of nanoparticles i.e. a controlled release kinetic and improved drug
loading.
In a 3 week stem cell
experiment, the technology improved the rate of osteogenic differentiation which
peaked one week earlier than on conventional and enabled comparable
proliferation. The technology approximately tripled the amount of mineralized
matrix after 3 weeks.
Commercial Value
The advent and the introduction of Nanobiotechnology in the
healthcare sector has had a vast impact in the field of drug discovery,
diagnostics and drug delivery. Such technology highlight opportunities that
exist at the intersection of nanotechnology and traditional pharmaceutical
R&D, though much uncertainty remains on how this will affect the industry.
Frost & Sullivan believes the global market for nanobiotechnology is
currently estimated at $21.1 billion and is expected to reach $36.2 billion by
2017.
The value of this technology is to increase the surface morphology of
a polymer scaffold drug delivery device and therefore offer an improved drug
loading.
The Technology
The invention is a process technology that complements polymer
scaffold technology in the regenerative medicine field.
A key aspect of scaffolds is the surface morphology, or the surface
area. A key goal in tissue engineering is an environment where cells can
proliferate that helps tissue development. The invention is a highly
configurable process which develops an open-cell, microporous membrane around a
scaffold. This acts to dramatically alter the surface morphology. This process
could be applied to the Desclaymr scaffold or any polymeric implantable
scaffold.
Intellectual Property Rights
Aarhus University has filed a patent application with priority date
December 2011