Description:
Complete Prepacked Two Chamber PET-Carbonylation Kits Based on a
Trap/Release of (11C)-Carbon Monoxide on a Solid Support
Technical Field
PET, Biotech, Pharma
Business opportunity
Research collaboration to validate the
technology
Current state of technology
Currently, the project has developed a prototype of the invention. In
addition, a range of biologically important carbon-11 carbonyl labelled
compounds has been synthesized utilizing the methodology.
Commercial Value
Nuclear medicine and PET represent two of the most widely used
molecular imaging modalities in clinical practice. Molecular imaging is a unique
form of diagnostic imaging that enables the characterization and measurement of
biological processes at the cellular and molecular levels.While nuclear medicine
has been recognized as a branch of medicine since the early 1970s, PET is a
relatively young market which did not begin gaining widespread acceptance as a
clinically viable tool in medicine until the mid-1990s.
In 2010, a total of 726 nuclear and PET imaging systems was shipped
within the US, with a revenue of 552.4 Mio dollar. US market revenues have
declined at a CAGR of 4.7 percent from 2007 to 2010 due to the continuing
recession. Projections are at a CAGR of 4.9 percent from 2010 to 2017. Growth
expectations for PET are primarily based an expected increase in demand due to
increased clinical scope and improved cost efficiency.
The Technology
A positron emission tomography (PET) scan is an imaging test that can
help reveal physiological information regarding how patients tissues and organs
are functioning. However, the technique is limited as there are not many
molecules that can be labelled with radioisotopes. Approximately 85% of all PET
examinations are performed with a single 18F-labelled sugar
analogue.
Not only are there not many tracer molecules, but there are problems
with the current ones, as many are made by methylation or fluorination of a
natural product. This changes the structure of the compound, therefore possibly
changing the mechanism of action. This can cause a range of problems, for
example, in relation to regulatory requirements. An alternative to 18-F and 11-C
methylation is 11-C carbonyl labelling, as this can be done without modifying
the chemical structure ? however, the methods of 11-C carbonyl labelling are
complex, limited and require sophisticated equipment.
Intellectual Property Rights
Aarhus University has filed a patent application in the US, with
priority date Sep 2011 and this has proceeded through the PCT phase.