Novel binding pocket for Sodium, Potassium regulation - A drugable target with new opportunities

Description:

 

 

References

[1] Morth JP, Pedersen BP, Toustrup-Jensen MS, Sørensen TL, Petersen J, Andersen JP, Vilsen B, Nissen P (2007). Crystal structure of the sodium-potassium pump. Nature 450, 1043-1049; and: Nyblom M, Reinhard L, Poulsen H, Andersson M, White S, Gourdon P, Vilsen B, Nissen P (2012). Crystal structure of the sodium pump in the Na+-bound state. In preparation

[2] Poulsen H, Khandelia H, Morth JP, Bublitz M, Mouritsen OG, Egebjerg J, Nissen P (2010). Neurological disease mutations compromise a C-terminal ion pathway in the Na(+)/K(+)-ATPase. Nature 467, 99-102

[3] Paulsen P, Nissen P, Poulsen H (2012). The C-terminal cavity of the Na,K-ATPase analyzed by docking and electrophysiology. Revised manuscript in review

[4] Bottger P, Doganli C, Lykke-Hartmann K (2012). Migraine- and dystonia-related disease-mutations of Na+/K+-ATPases: relevance of behavioral studies in mice to disease symptoms and neurological manifestations in humans. Neurosci Biobehav Rev. 36, 855-71.

[5] Yatime L, Laursen M, Morth JP, Esmann M, Nissen P, Fedosova NU (2011). Structural insights into the high affinity binding of cardiotonic steroids to the Na(+),K(+)-ATPase. J Struct Biol. 174, 296-306; and: Laursen M, Yatime L, Nissen P, Fedosova N (2012). The regulation of Na+,K+-ATPase function by ouabain. In preparation

[6] Lykke-Hartmann and coworkers, manuscripts in preparation

Patent Information:
For Information, Contact:
Kristine Howe Kjer
tidl Business Development Manager
Aarhus University
kkh@au.dk
Inventors:
Poul Nissen
Jens Preben Morth
Bente Vilsen
Jens Peter Andersen
Keywords:
Diagnostics
Therapeutics
White Biotech
z_DoNotUse_Pharma
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